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曾涛
19-11-22 10:11 toxicology  作者:

姓 名

曾涛

 

 

教授 (博士研究生导师)

 

 

 

0531-88382132

电子邮件

zengtao@sdu.edu.cn

通信地址

山东省济南市文化西路44

最高学位

博士

 

 

 

学术简历

20056月毕业于山东大学,获医学学士学位;同年7月推免为山东大学毒理学硕博连读研究生,20106月获医学博士学位,并留校工作。20111-20149月,任山东大学公共卫生学院讲师;201810-20199月,美国University of Arizona Donna Zhang实验室访问学者;20149-2019年8月,任山东大学公共卫生学院副教授;2019年9月-至今,山东大学公共卫生学院教授

研究方向

肝脏毒理学:环境/职业有害因素的肝脏毒性的分子机制及防治研究。(1)以氧化应激和肝脏巨噬细胞极化调控为研究切入点,探讨自噬、Nrf-2以及巨噬细胞极化在化学性肝损伤发病中的作用;(2)天然活性产物对化学性肝损伤的保护作用及其机制

学术/社会兼职    

中国毒理学会会员;中华预防医学会卫生毒理学分会青年委员;中国诱变剂学会致突变分会青年委员;山东省预防医学会卫生毒理学分会委员;欧洲自由基学会(Society of free radical-Europe)会员;国家自然科学基金函审专家;山东省自然科学基金结题评审专家;BLDE University journal of health science、世界胃肠病学杂志编委;Toxicology Mechanisms and MethodsFrontiers in Pharmacology等杂志特邀审稿人;ToxicologyFood and Chemical ToxicologyBBAMolecular Basis of DiseaseMolecular Nutrition and Food Research等杂志审稿人。

承担的主要研究课题

[1]. Nrf-2信号通路活化和枯否细胞极化调控在二烯丙基二硫(DADS)拮抗酒精性肝病中的作用 (81872653)国家自然科学基金面上项目 2019.01-2022.12  

[2]. 基于MAPK信号通路研究酒精性脂肪肝发病中PPAR-α抑制的分子机制 (81473004) 国家自然科学基金面上项目 2015.01-2018.12  

[3]. Kupffer细胞极化调控在酒精性肝病发病及防治中的作用 2017GSF18122) 山东省重点研发计划  2017.09-2019.12  

[4]. 酒精性脂肪肝发病的分子机制及干预研究(2011WLJH52)山东大学青年学者未来计划2015.07-2020.06

[5]. 细胞色素P4502E1在酒精性脂肪肝发病中的作用及分子机制 (81102153) 国家自 然科学基金青年基金 2012.1-2014.12

[6]. PI3K/Akt信号通路在酒精性脂肪肝发病中的作用 (20110131120064)教育部博士点基金 2011.12-2015.12

[7]. 二烯丙基二硫化物拮抗酒精性肝损伤及Nrf2/HO-1介导的保护机制(ZR2011HQ026) 山东省自然科学基金青年基金 2011.7-2014.7

[8]. 自噬溶酶体途径在酒精性脂肪肝发病中的作用(201104588) 中国博士后基金特别资助(第四批)

[9]. 酒精性肝损伤发病的分子机制及其干预研究(20100480253) 中国博士后基金面上项目(48)

[10]. 细胞色素P4502E1活化在酒精性脂肪肝发病中的作用研究(201002020) 山东省博士后创新项目基金

代表性学术论文 (2012--至今)

[1]. Zhao, H.J., Li, M.J., Zhang, M.P., et al., 2019. Allyl methyl trisulfide protected against acetaminophen (paracetamol)-induced hepatotoxicity by suppressing CYP2E1 and activating Nrf2 in mouse liver. Food & function 10, 2244-2253.通讯作者

[2]. Yang, R., Guan, M.J., Zhao, N., et al., 2019. Roles of extrahepatic lipolysis and the disturbance of hepatic fatty acid metabolism in TNF-alpha -induced hepatic steatosis. Toxicology 411, 172-180. 通讯作者

[3]. Li, M.J., Zeng, T., 2019. The deleterious effects of N,N-dimethylformamide on liver: A mini-review. Chem Biol Interact 298, 129-136. 通讯作者

[4]. Zeng, T., Zhang, C.L., Zhao, N., et al., 2018. Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver. Redox Biol 14, 295-304. 第一作者/通讯作者

[5]. Zhao, N., Guo, F.F., Xie, K.Q., et al., 2018. Targeting Nrf-2 is a promising intervention approach for the prevention of ethanol-induced liver disease. Cell Mol Life Sci 75, 3143-3157. 通讯作者

[6]. Zhao, N., Guan, M.J., Li, M.J., et al., 2018. Effects of garlic-derived lipid soluble organosulfur compounds on hematological parameters in mice. Journal of functional foods 46, 85-89. 通讯作者

[7]. Guan, M.J., Zhao, N., Xie, K.Q., et al., 2018. Hepatoprotective effects of garlic against ethanol-induced liver injury: A mini-review. Food Chem Toxicol 111, 467-473. 通讯作者

[8]. Zhao, Y.Y., Yang, R., Xiao, M., et al., 2017. Kupffer cells activation promoted binge drinking-induced fatty liver by activating lipolysis in white adipose tissues. Toxicology 390, 53-60 通讯作者

[9]. Zeng T., C.-L. Zhang, M. Xiao, et al., Critical roles of Kupffer cells in the pathogenesis of alcoholic liver disease: from basic science to clinical trials. Frontiers in Immunology, 2016. 7: p. 538.

[10]. Wang, Y., Zhao, Y., Li, M., Yu, S. and Zeng, T. 2016. Docosahexaenoic acid supplementation failed to attenuate chronic alcoholic fatty liver in mice. Acta Biochim Biophys Sin (Shanghai) 48, 482-484. (Corresponding author)

[11]. Zeng, T., Zhao, Y.Y. and Xie, K.Q. 2016. Does Intestinal Microbiota Protect Mice Against Acute/Binge Drinking-Induced Liver Injury? Alcohol Clin Exp Res 40, 1788-1790.

[12]. Zhao, Y.Y., Xiao, M., Zhang, C.L., Xie, K.Q. and Zeng, T. 2016. Associations between the tumor necrosis factor-alpha gene and interleukin-10 gene polymorphisms and risk of alcoholic liver disease: A meta-analysis. Clin Res Hepatol Gastroenterol 40, 428-439. (Corresponding author)

[13]. Chen YY, Zhang CL, Zhao XL, Xie KQ, Zeng T. Inhibition of cytochrome P4502E1 by chlormethiazole attenuated acute ethanol-induced fatty liver. Chem Biol Interact. 2014, 222C:18-26. (Corresponding author)

[14]. Zeng T, Zhang CL, Song FY, Zhao XL, Xie KQ.CMZ reversed chronic ethanol-induced disturbance of PPAR-α possibly by suppressing oxidative stress and PGC-1α acetylation, and activating the MAPK and GSK3β pathway. PLoS One. 2014, 9(6):e98658.

[15]. Zeng T, Zhang CL, Zhao XL, Xie KQ. Pentoxifylline for the treatment of nonalcoholic fatty liver disease: a meta-analysis of randomized double-blind, placebo-controlled studies. Eur J Gastroenterol Hepatol. 2014, 26(6):646-53.

[16]. Zeng T, Zhang CL, Song FY, Zhao XL, Yu LH, Zhu ZP, Xie KQ. The activation of HO-1/Nrf-2 contributes to the protective effects of diallyl disulfide (DADS) against ethanol-induced oxidative stress. Biochim Biophys Acta, 2013, 1830: 4848-4859.

[17]. Zeng T, Zhang CL, Zhao XL, Xie KQ. The roles of garlic on the lipid parameters: a systematic review of the literature. Crit Rev Food Sci Nutr, 2013, 53: 215-230

[18]. Zeng T, Zhang CL, Han XY, Zhao S, Xie KQ. Association between CD14-159C>T polymorphisms and the risk for alcoholic liver disease: a meta-analysis. Eur J Gastroenterol Hepatol, 2013, 25, 1183-1189.

[19]. Zeng T, Li Y, Zhang CL, Yu LH, Zhu ZP, Zhao XL, Xie KQ. Garlic oil suppressed the hematological disorders induced by chemotherapy and radiotherapy in tumor-bearing mice. J Food Sci, 2013, 78: H936-942.

[20]. Zeng T, Guo FF, Zhang CL, Song FY, Zhao XL, Xie KQ. Roles of Cytochrome P4502E1 Gene Polymorphisms and the Risks of Alcoholic Liver Disease: A Meta-Analysis. PloS one, 2013, 8:e54188.

[21]. Zeng T, Zhang CL, Song FY, Zhao XL, Yu LH, Zhu ZP, Xie KQ. PI3K/Akt pathway activation was involved in acute ethanol-induced fatty liver in mice. Toxicology, 2012, 296:56-66.

[22]. Zeng T, Zhang CL, Song FY, Zhao XL, Xie KQ. Garlic oil alleviated ethanol-induced fat accumulation via modulation of SREBP-1, PPAR-alpha, and CYP2E1. Food Chem Toxicol, 2012, 50:485-491

[23]. Zeng T, Guo FF, Zhang CL, Song FY, Zhao XL, Xie KQ. A meta-analysis of randomized, double-blind, placebo-controlled trials for the effects of garlic on serum lipid profiles. J Sci Food Agric, 2012, 92:1892-1902

[24]. Guo FF, Xie Q, An RF, Zeng T, Zhou W. The CD14--159C/T polymorphisms and the risks of tuberculosis: a meta-analysis. Infect Genet Evol. 2013, 18:277-83. (corresponding author)

[25]. Zeng T, Xie KQ. The differential modulation on cytochrome P450 enzymes by garlic components. Food Reviews International.2010, 26(4):353-363.

[26]. Yin HY, Guo Y, Song FY, Zeng T, Xie KQ. Toxicokinetic study of pyrrole adducts and its potential application for biological monitoring of 2,5-hexanedione subacute exposure.Int Arch Occup Environ Health. 2014, 87(6):655-62.

[27]. Zhang CL, Zeng T, Zhao XL, Xie KQ. Garlic oil attenuated nitrosodiethylamine-induced hepatocarcinogenesis by modulating the metabolic activation and detoxification enzymes. Int J Biol Sci. 2013, 9(3):237-45.

[28]. Chen J, Zeng T, Zhao X, Xie K, Bi Y, Zhong Z, Zhao X. Docosahexaenoic acid (DHA) ameliorates paraquat-induced pulmonary fibrosis in rats possibly through up-regulation of Smad 7 and SnoN. Food Chem Toxicol. 2013, 57:330-7.

[29]. Zhong Z, Zeng T, Xie K, Zhang C, Chen J, Bi Y, Zhao X.Elevation of 4-hydroxynonenal and malondialdehyde modified protein levels in cerebral cortex with cognitive dysfunction in rats exposed to 1-bromopropane.Toxicology. 2013, 306:16-23.

[30]. Song F, Han X, Zeng T, Zhang C, Zou C, Xie K.Changes in beclin-1 and micro-calpain expression in tri-ortho-cresyl phosphate-induced delayed neuropathy.Toxicol Lett. 2012, 210(3):276-84.

代表性著作(章节)

Zeng T and Xie KQ. “Chapter 19: Cytochrome P4502E1 GenePolymorphisms and the Risks of Ethanol-Induced Health Problems in Alcoholics”.In: “Molecular Aspects of Alcohol and Nutrition, 1st Edition” edited by VinoodB. Patel; Publisher: ElsevierScience; 11 Nov 2015

重要奖项

(1) 2011年山东省毒理学会青年毒理学工作者一等奖

(2) 2011年山东省研究生优秀科技创新成果二等奖

(3) 2008年获得山东大学研究生校长奖学金

 

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